I once read a biography on Twain that explained the problem: the Paige typesetter was so trouble-prone because it tried to imitate a human typesetter, picking each letter as it was typed in. The important fact about the Paige was that it proved that typesetting could not be done easily with this approach. Instead, entire blocks were cast of molten lead alloy and fitted into page frames. This has since been replaced with lithography, which uses a photographic image of the page, a far more simpler process. So all that a lithographer needs is "camera-ready" copy.
The Paige typesetter tried to duplicate the human typesetting process robotically in a time when machines were truly dumb. Lithography is based on the differing properties of oil and water. Basically the Paige told everyone that ther was no solution down the road to robotic typesetting. Odds are that with computers, a flawless Paige typesetter would be possible. But litography is so much cheaper, there is no need to even try to build one.
If copyright laws had been enforced, Twain would have never needed to bother with a typesetter.