The idea of state's rights made sense when the country was founded. It no longer makes as much sense. It encourages some states that are controlled by powerful oligarchies to tax the citizens to pay for freebies (free land, free services, low taxes or even no taxes for a period of time) to corporations to lure them away from their present locations. Mississippi will always be backward, because these sweetheart deals mean that these industries will become a powerful oligarchy, and continue to extract freebies from the taxpayers. Small businesses, that provide more jobs and tend to keep their money within the state, rarely get these juicy deals.
Voters in states that have few people. like Wyoming, can dominate the Senate and prevent innovations that would benefit a majority of the people.
I have lived in ten states, but I do not feel any special allegiance to any of them. The food and the culture are different (I prefer NM on both counts), and there are political differences (WA and MD are the best run, VA is far and away the worst), but the idea that this nation should allow different standards in education and tolerance is repulsive to me.